Anti-stress effects of cinnamon (Cassia zelynicum) bark extract in cold restraint stress rat model

The present study aims at investigating the anti-stress effects of cinnamon (Cassia zelynicum) bark extract in cold restrained stress (CRS) model. The cinnamon anti-stress effect was characterized using ulcer scoring, adrenal-gland weight, estimation of plasma glucose and cholesterol levels, as well as estimation of norepinephrine (NE) and corticosterone. Our results demonstrated that cinnamon is effective in minimizing stress responses by alleviating the increased level of ulcer scoring, plasma corticosterone, NE, glucose and total cholesterol levels which was induced in rats subjected to CRS. Thus, cinnamon is found to be effective in minimizing stress responses at a dose of 200 mg/kg thereby beneficial in stress therapy.